(4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol

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Chemical Name:(4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol
CAS No.:1312580-69-0
Molecular Formula:C₃₀H₃₃ClN₄O
Molecular Weight:501.071
Hs Code.:

Synonyms:(4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol

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Chemical Property of (4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol

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Technology Process of (4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol

There total 10 articles about (4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1312581-14-8
4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-benzoic acid ethyl ester

: 1312580-69-0
(4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol

Guidance literature:: 4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-benzoic acid ethyl ester; With lithium triethylborohydride; In tetrahydrofuran; for 4h;

With methanol; In tetrahydrofuran;

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1312580-69-0
(4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 30 - 40 °C

2.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1.83 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 °C

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 14 h / 95 °C / Nitrogen

4.1: N-iodo-succinimide / tetrahydrofuran; methanol / 1 h

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / Nitrogen

6.1: hydrogenchloride / ethanol; water / 2.5 h / 60 °C

6.2: pH 8

7.1: 1,1-dichloroethane; water / 3.5 h

8.1: bromo-catecholborane / dichloromethane / 1.5 h

9.1: caesium carbonate / 1,2-dimethoxyethane; DMPU 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 17 h / 50 °C

10.1: lithium triethylborohydride / tetrahydrofuran / 4 h

With hydrogenchloride; N-iodo-succinimide; bromo-catecholborane; tetra(n-butyl)ammonium hydrogensulfate; lithium triethylborohydride; caesium carbonate; sodium hydroxide; lithium diisopropyl amide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 1,1-dichloroethane; ethanol; hexane; dichloromethane; DMPU 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; water; acetonitrile; 5.1: Suzuki Coupling;

Reference yield:

: 1312581-16-0
4-[4-(4-chloro-3-iodo-1-methoxymethyl-7-azaindole)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

: 1312580-69-0
(4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / Nitrogen

2.1: hydrogenchloride / ethanol; water / 2.5 h / 60 °C

2.2: pH 8

3.1: 1,1-dichloroethane; water / 3.5 h

4.1: bromo-catecholborane / dichloromethane / 1.5 h

5.1: caesium carbonate / 1,2-dimethoxyethane; DMPU 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 17 h / 50 °C

6.1: lithium triethylborohydride / tetrahydrofuran / 4 h

With hydrogenchloride; bromo-catecholborane; lithium triethylborohydride; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; 1,1-dichloroethane; ethanol; dichloromethane; DMPU 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; water; 1.1: Suzuki Coupling;