Technology Process of 4-[4-(4-chloro-1-methoxymethyl-7-azaindole)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester
There total 3 articles about 4-[4-(4-chloro-1-methoxymethyl-7-azaindole)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,2-dimethoxyethane; water;
at 95 ℃;
for 14h;
Nitrogen;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / acetonitrile / 0.5 h / 20 °C / Inert atmosphere
1.2: 30 - 40 °C
2.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1.83 h / -78 °C / Inert atmosphere
2.2: 4 h / -78 °C
3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,2-dimethoxyethane; water / 14 h / 95 °C / Nitrogen
With
tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; sodium hydroxide; lithium diisopropyl amide;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1.83 h / -78 °C / Inert atmosphere
1.2: 4 h / -78 °C
2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,2-dimethoxyethane; water / 14 h / 95 °C / Nitrogen
With
caesium carbonate; lithium diisopropyl amide;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; water;