Technology Process of 4-[5-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-2-(2,2,2-trifluoro-acetyl)-pentyl]-benzoic acid
There total 6 articles about 4-[5-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-2-(2,2,2-trifluoro-acetyl)-pentyl]-benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 64 percent / acetic acid / ethanol / 25 °C
2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
2.2: tetrahydrofuran / 1 h / 25 °C
3.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C
3.2: 0.57 g / dimethylformamide / 9 h / 50 °C
4.1: 58 percent / sodium methoxide / methanol; dimethylformamide / 16 h / 75 °C
5.1: LiOH*H2O / methanol; H2O / 24 h / 25 °C
5.2: 100 percent / hydrochloric acid / H2O / 0.5 h / pH 1
With
lithium hydroxide; sodium methylate; sodium hexamethyldisilazane; sodium hydride; acetic acid;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.11.049
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 1 h / 25 °C
2.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C
2.2: 0.57 g / dimethylformamide / 9 h / 50 °C
3.1: 58 percent / sodium methoxide / methanol; dimethylformamide / 16 h / 75 °C
4.1: LiOH*H2O / methanol; H2O / 24 h / 25 °C
4.2: 100 percent / hydrochloric acid / H2O / 0.5 h / pH 1
With
lithium hydroxide; sodium methylate; sodium hexamethyldisilazane; sodium hydride;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.11.049
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C
1.2: 0.57 g / dimethylformamide / 9 h / 50 °C
2.1: 58 percent / sodium methoxide / methanol; dimethylformamide / 16 h / 75 °C
3.1: LiOH*H2O / methanol; H2O / 24 h / 25 °C
3.2: 100 percent / hydrochloric acid / H2O / 0.5 h / pH 1
With
lithium hydroxide; sodium methylate; sodium hydride;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.11.049
