3-[4-(Methoxycarbonyl)phenyl]propanoic acid

Base Information

• Chemical Name: 3-[4-(Methoxycarbonyl)phenyl]propanoic acid
• CAS No.: 151937-09-6
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Hs Code.: 2918990090
• Mol file: 151937-09-6.mol

Synonyms:3-(4-(methoxycarbonyl)phenyl)propionic acid;4-(2-carboxy-ethyl)-benzoic acid methyl ester;3-(4-carbomethoxyphenyl)propionic acid;Benzenepropanoic acid,4-(methoxycarbonyl);3-(4-(methoxycarbonyl)phenyl)propanoic acid;

Chemical Property of 3-[4-(Methoxycarbonyl)phenyl]propanoic acid

Chemical Property:

• Boiling Point: 360.5±25.0 °C(Predicted)
• PKA: 4.55±0.10(Predicted)
• PSA: 63.60000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 1.49040
• Solubility.: Methanol

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Carboxyethyl)benzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in the preparation of a potential inhibitor of GAR Tfase.

Technology Process of 3-[4-(Methoxycarbonyl)phenyl]propanoic acid

There total 4 articles about 3-[4-(Methoxycarbonyl)phenyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(2-carboxyvinyl)benzoic acid methyl ester (19473-96-2) → 3-(4-methoxycarbonylphenyl)propanoic acid (151937-09-6)

Guidance literature:

With hydrogen; In methanol; at 40 ℃; for 5h;

Reference yield: 88.0%

(E)-4-(methoxycarbonyl)cinnamic acid (117390-07-5) → 3-(4-methoxycarbonylphenyl)propanoic acid (151937-09-6)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; for 3h; under 2585.7 Torr;

Reference yield:

3-(4-(methoxycarbonyl)phenyl)propanoic acid methyl ester (40912-11-6) → 3-(4-methoxycarbonylphenyl)propanoic acid (151937-09-6)

Guidance literature:

3-(4-(methoxycarbonyl)phenyl)propanoic acid methyl ester; With methanol; sodium hydroxide; water; at 0 - 20 ℃; for 16h;

With hydrogenchloride; In diethyl ether; water;

upstream raw materials:

(E)-4-(methoxycarbonyl)cinnamic acid

3-(4-(methoxycarbonyl)phenyl)propanoic acid methyl ester

methyl 4-formylbenzoate

4-(2-carboxyvinyl)benzoic acid methyl ester

Downstream raw materials:

methyl 4-(2-cyanoethyl)benzoate

1,1,1-trifluoro-4-(4-(methoxycarbonyl)phenyl)butan-2-one

4-[5-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-2-(2,2,2-trifluoro-acetyl)-pentyl]-benzoic acid

di-tert-butyl N-{4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl}-L-glutamate