tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[(4-bromobenzenesulfonyl)-(benzyloxy)amino]butanoate

Base Information

• Chemical Name: tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[(4-bromobenzenesulfonyl)-(benzyloxy)amino]butanoate
• CAS No.: 1218922-50-9
• Molecular Formula: C₂₉H₃₃BrN₂O₇S
• Molecular Weight: 633.56

Synonyms:tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[(4-bromobenzenesulfonyl)-(benzyloxy)amino]butanoate

Chemical Property of tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[(4-bromobenzenesulfonyl)-(benzyloxy)amino]butanoate

Chemical Property:

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Technology Process of tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[(4-bromobenzenesulfonyl)-(benzyloxy)amino]butanoate

There total 1 articles about tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[(4-bromobenzenesulfonyl)-(benzyloxy)amino]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-(benzyloxy)-4-bromobenzenesulfonamide (1218922-49-6) + tert-butyl (2S)-4-{[(benzyloxy)carbonyl]amino}-2-hydroxybutanoate (849773-54-2) → tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[(4-bromobenzenesulfonyl)-(benzyloxy)amino]butanoate (1218922-50-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm901868z

Reference yield: 96.4%

tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[(4-bromobenzenesulfonyl)-(benzyloxy)amino]butanoate (1218922-50-9) + acetic acid (64-19-7,77671-22-8) → (R)-3-(4-bromophenylsulfonamido)-4-tert-butoxy-4-oxobutan-1-aminium acetate (1218922-52-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 17h;

DOI:10.1021/jm901868z

upstream raw materials:

N-(benzyloxy)-4-bromobenzenesulfonamide

tert-butyl (2S)-4-{[(benzyloxy)carbonyl]amino}-2-hydroxybutanoate

Downstream raw materials:

(R)-3-(4-bromophenylsulfonamido)-4-tert-butoxy-4-oxobutan-1-aminium acetate

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