1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal

Base Information

Chemical Name:1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal
CAS No.:102609-87-0
Molecular Formula:C₁₇H₂₅NO₅
Molecular Weight:323.389
Hs Code.:

Synonyms:1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal

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Chemical Property of 1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal

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Technology Process of 1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal

There total 5 articles about 1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67643-65-6,104917-72-8,104917-75-1
1,2,3,10,11,11a-hexahydro-10-hydroxy-5H-pyrrolo<1,2-b><2>benzazepine-5-one

: 102609-87-0
1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH / toluene / 15 h / Heating

2: 1.) O₃, 2.) dimethyl sulfide, HCl / 1.) MeOH, -77 deg C, 15 min, 2.) a) from -77 deg C to room temp., 2.5 h, b) room temp., overnight

With hydrogenchloride; dimethylsulfide; toluene-4-sulfonic acid; ozone; In toluene;
DOI:10.1021/jo00285a022

Reference yield:

: 67643-58-7
1,2,3,10,11,11a-hexahydro-5H-pyrrolo<1,2-b><2>benzazepine-5,10-dione

: 102609-87-0
1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NaBH₄ / methanol / 0.33 h / 0 °C

2: p-TsOH / toluene / 15 h / Heating

3: 1.) O₃, 2.) dimethyl sulfide, HCl / 1.) MeOH, -77 deg C, 15 min, 2.) a) from -77 deg C to room temp., 2.5 h, b) room temp., overnight

With hydrogenchloride; sodium tetrahydroborate; dimethylsulfide; toluene-4-sulfonic acid; ozone; In methanol; toluene;
DOI:10.1021/jo00285a022

Reference yield:

: 102609-86-9
1,2,3,11a-tetrahydropyrrolo<1,2-b><2>benzazepin-5-one

: 149-73-5
trimethyl orthoformate

: 102609-87-0
1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal

Guidance literature:: With hydrogenchloride; dimethylsulfide; ozone; Yield given. Multistep reaction; 1.) MeOH, -77 deg C, 15 min, 2.) a) from -77 deg C to room temp., 2.5 h, b) room temp., overnight;
DOI:10.1021/jo00285a022