(3-Bromo-2,6-dimethoxy-4-pyridyl)di-3,5-xylylphosphine oxide

Base Information

Chemical Name:(3-Bromo-2,6-dimethoxy-4-pyridyl)di-3,5-xylylphosphine oxide
CAS No.:442686-32-0
Molecular Formula:C₂₃H₂₅BrNO₃P
Molecular Weight:474.334
Hs Code.:
European Community (EC) Number:670-248-8
Nikkaji Number:J1.681.153J
Mol file:442686-32-0.mol

Synonyms:(3-bromo-2,6-dimethoxy-4-pyridyl)di-3,5-xylylphosphine oxide;442686-32-0;4-bis(3,5-dimethylphenyl)phosphoryl-3-bromo-2,6-dimethoxypyridine;(3-Bromo-2,6-dimethoxypyridin-4-yl)bis(3,5-dimethylphenyl)phosphine oxide

Suppliers and Price of (3-Bromo-2,6-dimethoxy-4-pyridyl)di-3,5-xylylphosphine oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (3-Bromo-2,6-dimethoxy-4-pyridyl)di-3,5-xylylphosphine oxide

Chemical Property:

Melting Point:220-222℃
Boiling Point:613.7±55.0 °C(Predicted)
PKA:-3.85±0.36(Predicted)
Density:1.36±0.1 g/cm3(Predicted)
XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:473.07554
Heavy Atom Count:29
Complexity:541

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC(=C1)P(=O)(C2=CC(=CC(=C2)C)C)C3=CC(=NC(=C3Br)OC)OC)C

Technology Process of (3-Bromo-2,6-dimethoxy-4-pyridyl)di-3,5-xylylphosphine oxide

There total 4 articles about (3-Bromo-2,6-dimethoxy-4-pyridyl)di-3,5-xylylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 442686-31-9
4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine

: 442686-32-0
4-[bis-(3,5-dimethyl-phenyl)-phosphinoyl]-3-bromo-2,6-dimethoxy-pyridine

Guidance literature:: With dihydrogen peroxide; In acetone; at 0 ℃;
DOI:10.1016/S0040-4039(02)00062-X

Reference yield:

: 13445-16-4
3-bromo-2,6-dimethoxypyridine

: 442686-32-0
4-[bis-(3,5-dimethyl-phenyl)-phosphinoyl]-3-bromo-2,6-dimethoxy-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 56 percent / tetrahydrofuran / -78 °C

2.1: 99 percent / H₂O₂ / acetone / 0 °C

With dihydrogen peroxide; lithium diisopropyl amide; In tetrahydrofuran; acetone;
DOI:10.1016/S0040-4039(02)00062-X

Reference yield:

: 34696-73-6
3,5-dimethyphenylmagnesium bromide

: 442686-32-0
4-[bis-(3,5-dimethyl-phenyl)-phosphinoyl]-3-bromo-2,6-dimethoxy-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 56 percent / tetrahydrofuran / -78 °C

2.1: 99 percent / H₂O₂ / acetone / 0 °C

With dihydrogen peroxide; lithium diisopropyl amide; In tetrahydrofuran; acetone;
DOI:10.1016/S0040-4039(02)00062-X