4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine

Base Information

• Chemical Name: 4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine
• CAS No.: 442686-31-9
• Molecular Formula: C₂₃H₂₅BrNO₂P
• Molecular Weight: 458.335

Synonyms:4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine

Chemical Property of 4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine

There total 2 articles about 4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-bromo-2,6-dimethoxypyridine (13445-16-4) + bis-(3,5-dimethylphenyl)chlorophosphine (74289-57-9) → 4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine (442686-31-9)

Guidance literature:

3-bromo-2,6-dimethoxypyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

bis-(3,5-dimethylphenyl)chlorophosphine; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(02)00062-X

Reference yield:

3,5-dimethyphenylmagnesium bromide (34696-73-6) → 4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine (442686-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 56 percent / tetrahydrofuran / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(02)00062-X

Reference yield: 99.0%

4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine (442686-31-9) → 4-[bis-(3,5-dimethyl-phenyl)-phosphinoyl]-3-bromo-2,6-dimethoxy-pyridine (442686-32-0)

Guidance literature:

With dihydrogen peroxide; In acetone; at 0 ℃;

DOI:10.1016/S0040-4039(02)00062-X

upstream raw materials:

3-bromo-2,6-dimethoxypyridine

bis-(3,5-dimethylphenyl)chlorophosphine

3,5-dimethyphenylmagnesium bromide

Downstream raw materials:

4-[bis-(3,5-dimethyl-phenyl)-phosphinoyl]-3-bromo-2,6-dimethoxy-pyridine

(S)-2,2',6,6'-tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine

(R)-(+)-2,2',6,6'-tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine

4,4'-bis-[bis-(3,5-dimethyl-phenyl)-phosphinoyl]-2,6,2',6'-tetramethoxy-[3,3']bipyridinyl

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 442686-31-9 4-[bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-bromo-2,6-dimethoxy-pyridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send