Quinoline-8-sulfonic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

Base Information

Chemical Name:Quinoline-8-sulfonic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide
CAS No.:215511-35-6
Molecular Formula:C₂₄H₁₈N₄O₃S
Molecular Weight:442.498
Hs Code.:

Synonyms:Quinoline-8-sulfonic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

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Chemical Property of Quinoline-8-sulfonic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

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Technology Process of Quinoline-8-sulfonic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

There total 1 articles about Quinoline-8-sulfonic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18704-37-5
quinoline-8-sulfonyl chloride

: 103343-47-1
3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one

: 215511-35-6
Quinoline-8-sulfonic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

Guidance literature:: With triethylamine; In chloroform; for 0.5h; Heating;
DOI:10.1016/S0223-5234(98)80048-2

Reference yield: 93.0%

: 105-36-2
ethyl bromoacetate

: 215511-35-6
Quinoline-8-sulfonic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

: 215511-41-4
[2-Oxo-5-phenyl-3-(quinoline-8-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/S0223-5234(98)80048-2

Reference yield:

: 215511-35-6
Quinoline-8-sulfonic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide

: [2-Oxo-5-phenyl-3-(1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NaH / dimethylformamide / 1 h / 20 °C

2: 64 percent / aq. NaOH / methanol / 24 h / Ambient temperature

3: 65 percent / H₂ / 5percent Pd/C / methanol / 15 h / 760 Torr / Ambient temperature

With sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(98)80048-2