Technology Process of 1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-methyl-β-carboline
There total 8 articles about 1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-methyl-β-carboline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate;
With
lithium borohydride;
In
tetrahydrofuran;
at 20 ℃;
for 9h;
With
hydrogenchloride; water;
In
tetrahydrofuran;
for 4h;
With
sodium hydroxide; water;
In
tetrahydrofuran;
DOI:10.1016/j.ejmech.2008.03.030
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride / 12 h / 0 - 20 °C
2.1: toluene-4-sulfonic acid / ethanol / 12 h / Reflux
3.1: triethylamine; trichloroisocyanuric acid / N,N-dimethyl-formamide / 12 h / -20 - 0 °C
4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.25 h / 0 °C
4.2: 4 h / 0 °C
5.1: lithium borohydride / tetrahydrofuran / 4 h / 0 - 20 °C
With
lithium borohydride; thionyl chloride; trichloroisocyanuric acid; sodium hydride; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; paraffin oil;
2.1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.bmc.2015.07.037
