ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate

Base Information

• Chemical Name: ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate
• CAS No.: 1145668-31-0
• Molecular Formula: C₂₄H₂₄N₂O₅
• Molecular Weight: 420.465
• Mol file: 1145668-31-0.mol

Synonyms:ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate

Chemical Property of ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate

There total 5 articles about ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3,4,5-trimethoxyphenyl)-β-carboline-3-carboxylic acid ethyl ester (1015792-22-9) + methyl iodide (74-88-4) → ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate (1145668-31-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5 - 2h;

DOI:10.1039/c5md00312a

Reference yield:

1-(3,4,5-trimethoxy)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (342013-69-8) → ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate (1145668-31-0)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 4 h / Reflux

2: sulfur / 5,5-dimethyl-1,3-cyclohexadiene / 8 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide / 0.5 - 2 h / 20 °C

With thionyl chloride; sodium hydride; sulfur; In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;

DOI:10.1039/c5md00312a

Reference yield:

ethyl 1-(3,4,5-trimethoxy)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (1160060-51-4) → ethyl 1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylate (1145668-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur / 5,5-dimethyl-1,3-cyclohexadiene / 8 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide / 0.5 - 2 h / 20 °C

With sodium hydride; sulfur; In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;

DOI:10.1039/c5md00312a

upstream raw materials:

1-(3,4,5-trimethoxy)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid

ethyl 1-(3,4,5-trimethoxy)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate

L-Tryptophan

1-(3,4,5-trimethoxyphenyl)-β-carboline-3-carboxylic acid ethyl ester

Downstream raw materials:

1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxylic acid

1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-methyl-β-carboline

N-(2-hydroxyethyl)-1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-formamide

1-(3,4,5-trimethoxy)phenyl-9-methyl-β-carboline-3-carboxaldehyde