C₂₂H₁₈FN₇O₃

Base Information

• Chemical Name: C₂₂H₁₈FN₇O₃
• CAS No.: 619331-11-2
• Molecular Formula: C₂₂H₁₈FN₇O₃
• Molecular Weight: 447.428
• Mol file: 619331-11-2.mol

Synonyms:C₂₂H₁₈FN₇O₃

Chemical Property of C₂₂H₁₈FN₇O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₁₈FN₇O₃

There total 8 articles about C₂₂H₁₈FN₇O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,4-Triazole (288-88-0) + 1-benzoyl-4-[(4-fluoro-7-chloro-6-azaindol-3-yl)oxoacety]piperazine (357263-37-7) → C22H18FN7O3 (619331-11-2)

Guidance literature:

With copper; potassium carbonate; at 160 ℃; for 4 - 7h;

Reference yield:

1,2,4-Triazole (288-88-0) + 1-(4-benzoylpiperazin-1-yl)-2-(7-bromo-4-fluoro-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (701213-94-7) → C22H18FN7O3 (619331-11-2)

Guidance literature:

Reference yield:

6-methoxy-pyridin-3-ylamine (6628-77-9) → C22H18FN7O3 (619331-11-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: tetrafluoroboric acid; sodium nitrite / ethanol; water / 3 h / 0 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / toluene / 2 h / Inert atmosphere; Sealed tube; Heating

3.1: sulfuric acid; nitric acid / 1 h / 20 - 80 °C / Inert atmosphere

4.1: tetrahydrofuran / 2.25 h / Inert atmosphere; Cooling

5.1: aluminum (III) chloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride / 8 h / 20 °C / Inert atmosphere

5.2: Inert atmosphere; Cooling with ice

6.1: N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

7.1: potassium carbonate; copper / 6 h / 140 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; aluminum (III) chloride; tetrafluoroboric acid; sulfuric acid; nitric acid; copper; potassium carbonate; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; 4.1: |Bartoli Indole Synthesis;

DOI:10.1021/jm3016377

upstream raw materials:

1,2,4-Triazole

1-benzoyl-4-[(4-fluoro-7-chloro-6-azaindol-3-yl)oxoacety]piperazine

1-(4-benzoylpiperazin-1-yl)-2-(7-bromo-4-fluoro-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

6-methoxy-pyridin-3-ylamine