Technology Process of 2,3,4,5-tetra-O-benzyl-5-(1,3-ditiolan-2-yl)-L-galactose
There total 6 articles about 2,3,4,5-tetra-O-benzyl-5-(1,3-ditiolan-2-yl)-L-galactose which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,3,4,5-tetra-O-benzyl-D-galactose ethylene dithioacetal;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 0.5h;
With
triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
DOI:10.1016/j.tetlet.2012.08.127
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine; dmap / 7 h / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 2 h / 0 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h
4.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C
4.2: -78 - 20 °C
With
pyridine; dmap; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
4.1: |Swern Oxidation / 4.2: |Swern Oxidation;
DOI:10.1016/j.tetlet.2012.08.127
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
1.2: 2 h / 0 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h
3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C
3.2: -78 - 20 °C
With
oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1016/j.tetlet.2012.08.127