4-(tert-butyl-dimethylsilanyloxy)-3,5-dimethylbenzaldehyde

Base Information

• Chemical Name: 4-(tert-butyl-dimethylsilanyloxy)-3,5-dimethylbenzaldehyde
• CAS No.: 1458623-57-8
• Molecular Formula: C₁₅H₂₄O₂Si
• Molecular Weight: 264.44
• Mol file: 1458623-57-8.mol

Synonyms:4-(tert-butyl-dimethylsilanyloxy)-3,5-dimethylbenzaldehyde

Chemical Property of 4-(tert-butyl-dimethylsilanyloxy)-3,5-dimethylbenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(tert-butyl-dimethylsilanyloxy)-3,5-dimethylbenzaldehyde

There total 3 articles about 4-(tert-butyl-dimethylsilanyloxy)-3,5-dimethylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-hydroxy-3,5-dimethylbenzaldehyde (2233-18-3) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-(tert-butyl-dimethylsilanyloxy)-3,5-dimethylbenzaldehyde (1458623-57-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.orglett.6b00012

Reference yield:

4-hydroxy-3,5-dimethylbenzaldehyde (2233-18-3) + t-butyldimethylsiyl triflate (69739-34-0) → 4-(tert-butyl-dimethylsilanyloxy)-3,5-dimethylbenzaldehyde (1458623-57-8)

Guidance literature:

With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1002/adsc.201401028

Reference yield:

2.6-dimethylphenol (576-26-1,25134-01-4) + tert-butyldimethylsilyl chloride (18162-48-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-(tert-butyl-dimethylsilanyloxy)-3,5-dimethylbenzaldehyde (1458623-57-8)

Guidance literature:

2.6-dimethylphenol; N,N-dimethyl-formamide; With trichlorophosphate; In acetonitrile;

tert-butyldimethylsilyl chloride; With 1H-imidazole; dmap; In DMF (N,N-dimethyl-formamide);

upstream raw materials:

2.6-dimethylphenol

tert-butyldimethylsilyl chloride

N,N-dimethyl-formamide

4-hydroxy-3,5-dimethylbenzaldehyde

Downstream raw materials:

3-(4-hydroxy-3,5-dimethylphenyl)-2-propenoic acid