2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Base Information

Chemical Name:2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine
CAS No.:459425-75-3
Molecular Formula:C₂₉H₄₇N₃O₇SSi₂
Molecular Weight:637.945
Hs Code.:

Synonyms:2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Suppliers and Price of 2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

There total 3 articles about 2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 459425-74-2
N-benzyl-C-[4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-3-yl]-methanesulfonamide

: 459425-75-3
2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Guidance literature:: With thionyl diimidazole; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

: 3989-45-5
N-benzylmethanesulfonamide

: 459425-75-3
2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran / 1 h / -30 °C

1.2: 71 percent / tetrahydrofuran / 5 h / -30 °C

2.1: 85 percent / thionyl diimidazole / tetrahydrofuran / 12 h / 20 °C

With n-butyllithium; thionyl diimidazole; In tetrahydrofuran;

Reference yield:

: 90813-54-0
2',5'-bis-O-tert-butyldimethylsilyl-3'-ketouridine

: 459425-75-3
2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran / 1 h / -30 °C

1.2: 71 percent / tetrahydrofuran / 5 h / -30 °C

2.1: 85 percent / thionyl diimidazole / tetrahydrofuran / 12 h / 20 °C

With n-butyllithium; thionyl diimidazole; In tetrahydrofuran;