2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Base Information

Chemical Name:2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine
CAS No.:459425-76-4
Molecular Formula:C₂₃H₃₃N₃O₇SSi
Molecular Weight:523.682
Hs Code.:

Synonyms:2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

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Chemical Property of 2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

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Technology Process of 2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

There total 4 articles about 2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 459425-75-3
2',5'-bis(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

: 459425-76-4
2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Guidance literature:: With trifluoroacetic acid; at -20 ℃; for 1.5h;

Reference yield:

: 3989-45-5
N-benzylmethanesulfonamide

: 459425-76-4
2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran / 1 h / -30 °C

1.2: 71 percent / tetrahydrofuran / 5 h / -30 °C

2.1: 85 percent / thionyl diimidazole / tetrahydrofuran / 12 h / 20 °C

3.1: 96 percent / aq. TFA / 1.5 h / -20 °C

With n-butyllithium; thionyl diimidazole; trifluoroacetic acid; In tetrahydrofuran;

Reference yield:

: 90813-54-0
2',5'-bis-O-tert-butyldimethylsilyl-3'-ketouridine

: 459425-76-4
2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran / 1 h / -30 °C

1.2: 71 percent / tetrahydrofuran / 5 h / -30 °C

2.1: 85 percent / thionyl diimidazole / tetrahydrofuran / 12 h / 20 °C

3.1: 96 percent / aq. TFA / 1.5 h / -20 °C

With n-butyllithium; thionyl diimidazole; trifluoroacetic acid; In tetrahydrofuran;