1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone

Base Information

• Chemical Name: 1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone
• CAS No.: 354116-77-1
• Molecular Formula: C₁₃H₁₆N₂O₄
• Molecular Weight: 264.281
• Mol file: 354116-77-1.mol

Synonyms:1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone

Chemical Property of 1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone

There total 4 articles about 1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-methoxycarbonyl-3-methyl-3-(2'-nitroethyl)oxindol (354116-74-8) → 3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone (354116-76-0) + 1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone (354116-77-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; for 26.5h; under 2327.17 Torr;

DOI:10.3987/com-01-9177

Reference yield: 78.0%

1-methoxycarbonyl-3-methyl-3-(2'-nitroethyl)oxindol (354116-74-8) → 1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone (354116-77-1)

Guidance literature:

With hydrogen; nickel; In methanol;

DOI:10.3987/com-01-9177

Reference yield:

methyl 3-methyl-2-oxoindoline-1-carboxylate (354116-71-5) → 1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone (354116-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / 2,2,6,6-tetramethylpiperidine / benzene; tetrahydrofuran / 0.17 h / -80 °C

2: 78 percent / H₂ / 80 percentPtO₂ / ethanol / 26.5 h / 2327.17 Torr

With 2,2,6,6-tetramethyl-piperidine; hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; benzene;

DOI:10.3987/com-01-9177

upstream raw materials:

1-methoxycarbonyl-3-methyl-3-(2'-nitroethyl)oxindol

methyl 3-methyl-2-oxoindoline-1-carboxylate

2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid