2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid

Base Information

• Chemical Name: 2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid
• CAS No.: 354116-67-9
• Molecular Formula: C₁₇H₁₇NO₄S
• Molecular Weight: 331.392
• Mol file: 354116-67-9.mol

Synonyms:2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid

Chemical Property of 2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid

There total 1 articles about 2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

C-methoxy-N-phenyl-O-(2-phenylsulfanylpropanoyl)hydroxamic acid (354116-62-4) → 3-methyl-2-oxo-3-phenylsulfanyl-2,3-dihydro-indole-1-carboxylic acid methyl ester (354116-66-8) + 2-(4-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid + 2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid (354116-67-9)

Guidance literature:

With potassium hydride; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at -80 - 20 ℃; for 1h;

DOI:10.3987/com-01-9177

Reference yield: 52.0%

2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid (354116-67-9) → 3-methyl-2-oxo-3-phenylsulfanyl-2,3-dihydro-indole-1-carboxylic acid methyl ester (354116-66-8)

Guidance literature:

With sodium acetate; In acetic anhydride; at 60 - 70 ℃; for 3h;

DOI:10.3987/com-01-9177

Reference yield:

2-(2-methoxycarbonylamino-phenyl)-2-phenylsulfanyl-propionic acid (354116-67-9) → 1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone (354116-77-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 52 percent / sodium acetate / acetic anhydride / 3 h / 60 - 70 °C

2: 78 percent / n-BuSnH; AIBN / benzene / 0.67 h / Heating

3: 83 percent / 2,2,6,6-tetramethylpiperidine / benzene; tetrahydrofuran / 0.17 h / -80 °C

4: 78 percent / H₂ / 80 percentPtO₂ / ethanol / 26.5 h / 2327.17 Torr

With 2,2,6,6-tetramethyl-piperidine; n-butyl tin hydride; 2,2'-azobis(isobutyronitrile); hydrogen; sodium acetate; platinum(IV) oxide; In tetrahydrofuran; ethanol; acetic anhydride; benzene;

DOI:10.3987/com-01-9177

upstream raw materials:

C-methoxy-N-phenyl-O-(2-phenylsulfanylpropanoyl)hydroxamic acid

Downstream raw materials:

3-methyl-2-oxo-3-phenylsulfanyl-2,3-dihydro-indole-1-carboxylic acid methyl ester

3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone

1-hydroxy-3-(2'-methoxycarbonylamino)phenyl-3-methyl-2-pyrrolidone