2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide

Base Information

Chemical Name:2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide
CAS No.:1340592-16-6
Molecular Formula:C₂₁H₁₉ClF₆N₄O
Molecular Weight:492.851
Hs Code.:

Synonyms:2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide

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Chemical Property of 2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide

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Technology Process of 2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide

There total 6 articles about 2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 289686-69-7
2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

: 1340592-18-8
(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methyl-amine

: 1340592-16-6
2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 2h;

Reference yield:

: 1340592-17-7
(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-carbamic acid tert-butyl ester

: 1340592-16-6
2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 40 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 30720-25-3
ethyl 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 1340592-16-6
2-(3,5-bis-trifluoromethyl-phenyl)-N-(4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 35 °C

1.2: 20 °C / pH 4

2.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 6 h / 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

3.2: 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 40 °C

With diphenyl phosphoryl azide; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;