2,10-dihydroxy-7,8,9,11-tetramethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

Base Information

Chemical Name:2,10-dihydroxy-7,8,9,11-tetramethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one
CAS No.:1380309-27-2
Molecular Formula:C₂₈H₂₉NO₉S
Molecular Weight:555.606
Hs Code.:

Synonyms:2,10-dihydroxy-7,8,9,11-tetramethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

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Chemical Property of 2,10-dihydroxy-7,8,9,11-tetramethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

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Technology Process of 2,10-dihydroxy-7,8,9,11-tetramethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

There total 7 articles about 2,10-dihydroxy-7,8,9,11-tetramethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380308-57-5
7-hydroxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-N-(p-methylphenyl)sulfonyl-1,2,3,4-tetrahydroisoquinoline

: 1380309-29-4
10-hydroxy-2,7,8,9,11-pentamethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

: 1380309-27-2
2,10-dihydroxy-7,8,9,11-tetramethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

Guidance literature:: With oxovanadium(V) fluoride; trifluoromethylsulfonic anhydride; trifluoroacetic acid; In dichloromethane; ethyl acetate; at 0 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.04.007

Reference yield:

: 1380309-68-1
7-benzyloxy-6-methoxy-1-(3',4',5'-trimethoxyphenethyl)-N-(p-methylphenyl)sulfonyl-1,2,3,4-tetrahydroisoquinoline

: 1380309-29-4
10-hydroxy-2,7,8,9,11-pentamethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

: 1380309-27-2
2,10-dihydroxy-7,8,9,11-tetramethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C / Inert atmosphere

2: oxovanadium(V) fluoride; trifluoromethylsulfonic anhydride; trifluoroacetic acid / dichloromethane; ethyl acetate / 1.5 h / 0 °C / Inert atmosphere

With oxovanadium(V) fluoride; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2012.04.007

Reference yield:

: 25173-72-2
3-(3,4,5-trimethoxyphenyl)propanoic acid

: 1380309-29-4
10-hydroxy-2,7,8,9,11-pentamethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

: 1380309-27-2
2,10-dihydroxy-7,8,9,11-tetramethoxy-3-(p-methylphenyl)sulfonyl-3,3a,4,5-tetrahydrobenzo[6,7]cyclohepta[1,2,3-ij]isoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: trichlorophosphate / acetonitrile / 1 h / Inert atmosphere; Reflux

3: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 20 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C / Inert atmosphere

6: oxovanadium(V) fluoride; trifluoromethylsulfonic anhydride; trifluoroacetic acid / dichloromethane; ethyl acetate / 1.5 h / 0 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; oxovanadium(V) fluoride; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.007