N-[1-(benzyloxycarbonylmethyl-carbamoyl)-2-methyl-propyl]-succinamic acid

Base Information

• Chemical Name: N-[1-(benzyloxycarbonylmethyl-carbamoyl)-2-methyl-propyl]-succinamic acid
• CAS No.: 442900-82-5
• Molecular Formula: C₁₈H₂₄N₂O₆
• Molecular Weight: 364.398

Synonyms:N-[1-(benzyloxycarbonylmethyl-carbamoyl)-2-methyl-propyl]-succinamic acid

Chemical Property of N-[1-(benzyloxycarbonylmethyl-carbamoyl)-2-methyl-propyl]-succinamic acid

Chemical Property:

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Technology Process of N-[1-(benzyloxycarbonylmethyl-carbamoyl)-2-methyl-propyl]-succinamic acid

There total 2 articles about N-[1-(benzyloxycarbonylmethyl-carbamoyl)-2-methyl-propyl]-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-L-Val-Gly-OBzl (64918-37-2) → N-[1-(benzyloxycarbonylmethyl-carbamoyl)-2-methyl-propyl]-succinamic acid (442900-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.25 h

2: 474 mg / pyridine / CH₂Cl₂; dimethylformamide / 3 h

With pyridine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00179-5

Reference yield:

succinic acid anhydride (108-30-5) + H-Val-Gly-OBzl*TFA (74939-29-0) → N-[1-(benzyloxycarbonylmethyl-carbamoyl)-2-methyl-propyl]-succinamic acid (442900-82-5)

Guidance literature:

With pyridine; In dichloromethane; N,N-dimethyl-formamide; for 3h;

DOI:10.1016/S0040-4020(02)00179-5

Reference yield: 70.0%

H-Val-Gly-OMe (121975-22-2) + N-[1-(benzyloxycarbonylmethyl-carbamoyl)-2-methyl-propyl]-succinamic acid (442900-82-5) → ((S)-2-{3-[(R)-1-(Methoxycarbonylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/S0040-4020(02)00179-5

upstream raw materials:

succinic acid anhydride

H-Val-Gly-OBzl*TFA

Boc-L-Val-Gly-OBzl

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