bis

Base Information

• Chemical Name: bis
• CAS No.: 141043-95-0
• Molecular Formula: C₃₈H₄₂N₄O₆S₂*2ClH
• Molecular Weight: 787.829
• Mol file: 141043-95-0.mol

Synonyms:bis

Chemical Property of bis

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis

There total 6 articles about bis which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

bis (141043-94-9) → bis (141043-95-0)

Guidance literature:

With hydrogenchloride; methyl-phenyl-thioether; acetic acid; for 0.5h; Ambient temperature;

DOI:10.1021/jm00088a028

Reference yield:

di-t-butoxycarbonyl-L-cystine (10389-65-8) → bis (141043-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / diisopropylethylamine (DIEA), 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / dimethylformamide / 24 h / Heating

2: 92 percent / 1.75 N HCl/glacial HOAc, thioanisole / 0.5 h / Ambient temperature

With hydrogenchloride; methyl-phenyl-thioether; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00088a028

Reference yield:

Boc-D-Phe-OH (18942-49-9) → bis (141043-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 34 percent / dicyclohexylamine (DCHA) / dimethylformamide / 20 h / Ambient temperature

2: 98 percent / 1.7 N HCl/glacial HOAc, anisole / 0.75 h / Ambient temperature

3: 100 percent / diisopropylethylamine (DIEA), 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / dimethylformamide / 24 h / Heating

4: 92 percent / 1.75 N HCl/glacial HOAc, thioanisole / 0.5 h / Ambient temperature

With hydrogenchloride; methyl-phenyl-thioether; benzotriazol-1-ol; acetic acid; methoxybenzene; N-ethyl-N,N-diisopropylamine; N-cyclohexyl-cyclohexanamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00088a028

upstream raw materials:

bis

di-t-butoxycarbonyl-L-cystine

Boc-D-Phe-OH

benzyl bromide

Downstream raw materials:

bis