C₁₂H₁₈N₂O₃

Base Information

• Chemical Name: C₁₂H₁₈N₂O₃
• CAS No.: 1016713-15-7
• Molecular Formula: C₁₂H₁₈N₂O₃
• Molecular Weight: 238.287
• Mol file: 1016713-15-7.mol

Synonyms:C₁₂H₁₈N₂O₃

Chemical Property of C₁₂H₁₈N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₈N₂O₃

There total 3 articles about C₁₂H₁₈N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) + ethylenediamine (107-15-3,85404-18-8) → C12H18N2O3 (1016713-15-7)

Guidance literature:

(3,4-Dimethoxyphenyl)acetic acid; With 1-hydroxy-pyrrolidine-2,5-dione; diisopropyl-carbodiimide; In chloroform; at 20 ℃; for 1h;

ethylenediamine; In chloroform; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2013.07.026

Reference yield:

tert-butyl (2-(2-(3,4-dimethoxyphenyl)acetamido)ethyl)carbamate → C12H18N2O3 (1016713-15-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1016/j.ejmech.2019.111880

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → C12H18N2O3 (1016713-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.ejmech.2019.111880

upstream raw materials:

(3,4-Dimethoxyphenyl)acetic acid

ethylenediamine

Downstream raw materials:

C₃₂H₃₆F₃N₅O₅