(S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid

Base Information

Chemical Name:(S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid
CAS No.:696662-07-4
Molecular Formula:C₂₇H₂₇NO₅S
Molecular Weight:477.581
Hs Code.:

Synonyms:(S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid

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Chemical Property of (S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid

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Technology Process of (S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid

There total 8 articles about (S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310430-98-8
C₁₇H₁₇NO₄S₂

: 222555-06-8
ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

: 696662-07-4
(S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 - 90 °C

2: water; sodium hydroxide / methanol / 16 h / 20 - 25 °C

With water; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.020

Reference yield:

: 696661-81-1
ethyl (2S)-2-ethoxy-3-(4-{2-[5-methyl-2-(5-phenylthiophen-2-yl)-1,3-oxazol-4-yl]ethoxy}phenyl)propanoate

: 696662-07-4
(S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 - 25 ℃; for 16h;
DOI:10.1016/j.bmcl.2011.03.020

Reference yield:

: 19163-21-4
5-phenylthiophene-2-carboxaldehyde

: 696662-07-4
(S)-2-ethoxy-3-(4-(2-(5-methyl-2-(5-phenylthiophen-2-yl)oxazol-4-yl)ethoxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride; acetic acid / 1 h / 0 °C

2: trichlorophosphate / 1,2-dichloro-ethane / 14 h / Reflux

3: N,N-dimethyl-formamide / 4 h / 25 - 30 °C

4: sulfuric acid; water / 16 h / Reflux

5: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 10 °C

6: triethylamine / dichloromethane / 2 h / 25 °C

7: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 - 90 °C

8: water; sodium hydroxide / methanol / 16 h / 20 - 25 °C

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; water; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.020