(6S)-6-(benzylamine)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate

Base Information

• Chemical Name: (6S)-6-(benzylamine)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate
• CAS No.: 1044512-99-3
• Molecular Formula: C₁₈H₁₈F₃NO₃S
• Molecular Weight: 385.407
• Mol file: 1044512-99-3.mol

Synonyms:(6S)-6-(benzylamine)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate

Chemical Property of (6S)-6-(benzylamine)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

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Technology Process of (6S)-6-(benzylamine)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate

There total 1 articles about (6S)-6-(benzylamine)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

trifluoromethylsulfonic anhydride (358-23-6) + (6S)-6-[benzylamino]-5,6,7,8-tetrahydronaphthalen-1-ol (1089179-55-4) → (6S)-6-(benzylamine)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate (1044512-99-3)

Guidance literature:

In dichloromethane; at -78 ℃; for 1.5h;

Reference yield: 56.0%

(6S)-6-(benzylamine)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate (1044512-99-3) + 1,3,5-trimethylpyrazole-4-boronic acid pinacol ester (844891-04-9) → (2S)-benzyl-[5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amine (1044513-00-9)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 6h; Product distribution / selectivity; Heating / reflux;

Reference yield: 56.0%

(6S)-6-(benzylamine)-5,6,7,8-tetrahydronaphthalen-1-yl trifluoromethanesulfonate (1044512-99-3) + N-benzyl-N-tert-butyloxycarbonyl-N-[(2S)-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]amine (1088583-53-2) + 1,3,5-trimethylpyrazole-4-boronic acid pinacol ester (844891-04-9) → (2S)-benzyl-[5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amine (1044513-00-9)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; for 6.16667h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

trifluoromethylsulfonic anhydride

(6S)-6-[benzylamino]-5,6,7,8-tetrahydronaphthalen-1-ol

Downstream raw materials:

(2S)-benzyl-[5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amine