5-phenoxy-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone

Base Information

• Chemical Name: 5-phenoxy-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone
• CAS No.: 338405-34-8
• Molecular Formula: C₁₈H₁₃N₅O₂
• Molecular Weight: 331.334
• Mol file: 338405-34-8.mol

Synonyms:5-phenoxy-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone

Chemical Property of 5-phenoxy-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone

Chemical Property:

Purity/Quality:

5-PHENOXY-2-PHENYL-6-(1H-1,2,4-TRIAZOL-3-YL)-3(2H)-PYRIDAZINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-phenoxy-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone

There total 5 articles about 5-phenoxy-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N,N-dimethyl-N′-[(6-oxo-4-phenoxy-1-phenyl-1,6-dihydropyridazin-3-yl)carbonyl]formamidine (338405-12-2) → 5-phenoxy-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone (338405-34-8)

Guidance literature:

With hydrazine hydrate; acetic acid; at 90 ℃; for 1.5h;

Reference yield:

sodium phenoxide (139-02-6) → 5-phenoxy-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone (338405-34-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 20 h / 20 °C

2: ammonia / methanol / 0.75 h / 20 °C

3: 0.25 h / 90 °C

4: hydrazine hydrate; acetic acid / 1.5 h / 90 °C

With ammonia; hydrazine hydrate; acetic acid; In methanol;

Reference yield:

methyl 5-chloro-3-oxo-2-phenyl-2,3-dihydropyridazine-6-carboxylate (129109-17-7) → 5-phenoxy-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone (338405-34-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 20 h / 20 °C

2: ammonia / methanol / 0.75 h / 20 °C

3: 0.25 h / 90 °C

4: hydrazine hydrate; acetic acid / 1.5 h / 90 °C

With ammonia; hydrazine hydrate; acetic acid; In methanol;

upstream raw materials:

sodium phenoxide

methyl 5-chloro-3-oxo-2-phenyl-2,3-dihydropyridazine-6-carboxylate

methyl 3-oxo-5-phenoxy-2-phenyl-2,3-dihydropyridazine-6-carboxylate

3-oxo-5-phenoxy-2-phenyl-2,3-dihydropyridazine-6-carboxamide

Downstream raw materials:

5-benzylamino-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone

5-isopropylamino-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone

5-cyclohexylamino-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone