Technology Process of 3-Methanesulfonyl-2-methyl-4-(pyridin-3-yloxy)-benzoic acid methyl ester
There total 6 articles about 3-Methanesulfonyl-2-methyl-4-(pyridin-3-yloxy)-benzoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 130 ℃;
for 2h;
DOI:10.1021/jm960768n
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) HNO3, 2.) HCl / 1.) 0 - 5 deg C, 1 h, 2.) reflux, 6 h
2: 70 percent / H2 / Raney-Ni / methanol / 3 h / 45 °C / 760 Torr
3: 1.) aq. NaNO2, H2SO4, H3PO4, 2.) liq. SO2, FeSO4*7H2O, Cu / 1.) 5 deg C - 10 deg C, overnight, 2.) from -15 deg C to RT, 4 h
4: K2CO3 / dimethylformamide / 24 h / Ambient temperature
5: 78 percent / K2CO3 / dimethylformamide / 2 h / 130 °C
With
hydrogenchloride; phosphoric acid; sulfuric acid; sulfur dioxide; hydrogen; nitric acid; copper; potassium carbonate; sodium nitrite;
nickel;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960768n
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 70 percent / H2 / Raney-Ni / methanol / 3 h / 45 °C / 760 Torr
2: 1.) aq. NaNO2, H2SO4, H3PO4, 2.) liq. SO2, FeSO4*7H2O, Cu / 1.) 5 deg C - 10 deg C, overnight, 2.) from -15 deg C to RT, 4 h
3: K2CO3 / dimethylformamide / 24 h / Ambient temperature
4: 78 percent / K2CO3 / dimethylformamide / 2 h / 130 °C
With
phosphoric acid; sulfuric acid; sulfur dioxide; hydrogen; copper; potassium carbonate; sodium nitrite;
nickel;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960768n
