1-benzyl-1-(2-(dimethylamino)-2-oxoethyl)piperidinium bromide

Base Information

• Chemical Name: 1-benzyl-1-(2-(dimethylamino)-2-oxoethyl)piperidinium bromide
• CAS No.: 1380490-93-6
• Molecular Formula: Br*C₁₆H₂₅N₂O
• Molecular Weight: 341.291
• Mol file: 1380490-93-6.mol

Synonyms:1-benzyl-1-(2-(dimethylamino)-2-oxoethyl)piperidinium bromide

Chemical Property of 1-benzyl-1-(2-(dimethylamino)-2-oxoethyl)piperidinium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-benzyl-1-(2-(dimethylamino)-2-oxoethyl)piperidinium bromide

There total 1 articles about 1-benzyl-1-(2-(dimethylamino)-2-oxoethyl)piperidinium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C9H18N2O (102312-62-9) + benzyl bromide (100-39-0) → 1-benzyl-1-(2-(dimethylamino)-2-oxoethyl)piperidinium bromide (1380490-93-6)

Guidance literature:

In acetonitrile; at 20 ℃; for 10h;

DOI:10.1016/j.tet.2012.04.015

Reference yield: 80.0%

1-benzyl-1-(2-(dimethylamino)-2-oxoethyl)piperidinium bromide (1380490-93-6) → N,N-dimethyl-2-(2-methylphenyl)-2-(piperidin-1-yl)acetamide (1380490-99-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2012.04.015

Reference yield:

1-benzyl-1-(2-(dimethylamino)-2-oxoethyl)piperidinium bromide (1380490-93-6) → 2-bromo-N,N-dimethyl-2-(2-methylphenyl)acetamide (1380491-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 0 °C / Inert atmosphere

2: bromocyane / dichloromethane / 20 °C / Inert atmosphere

With bromocyane; potassium tert-butylate; In tetrahydrofuran; dichloromethane; 1: Sommelet-Hauser rearrangement;

DOI:10.1016/j.tet.2012.04.015

upstream raw materials:

C₉H₁₈N₂O

benzyl bromide

Downstream raw materials:

N,N-dimethyl-2-(2-methylphenyl)-2-(piperidin-1-yl)acetamide

2-bromo-N,N-dimethyl-2-(2-methylphenyl)acetamide