trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-acetonitrile

Base Information

Chemical Name:trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-acetonitrile
CAS No.:1418002-90-0
Molecular Formula:C₁₆H₁₇N₅O₂
Molecular Weight:311.343
Hs Code.:

Synonyms:trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-acetonitrile

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Chemical Property of trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-acetonitrile

Chemical Property:

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Technology Process of trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-acetonitrile

There total 4 articles about trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1266328-42-0
2-((1r,4r)-4-aminocyclohexyl)acetonitrile

: 85967-19-7
4-chloro-3-nitro-[1,5]naphthyridine

: 1418002-90-0
trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-acetonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 239074-29-4
trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1418002-90-0
trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 5 h / 0 - 20 °C

2: dimethyl sulfoxide / 4 h / 90 °C

3: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 120 °C / Microwave irradiation

With pyridine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 683269-95-6
N-[trans-4-[[(methylsulfonyl)oxy]methyl]cyclohexyl]carbamic acid tert-butyl ester

: 1418002-90-0
trans-[4-(3-nitro-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 4 h / 90 °C

2: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 120 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;