trans-[1-(4-cyanomethyl-cyclohexyl)-1H-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-ylmethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:trans-[1-(4-cyanomethyl-cyclohexyl)-1H-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-ylmethyl]-carbamic acid tert-butyl ester
CAS No.:1418003-24-3
Molecular Formula:C₂₃H₂₈N₆O₂
Molecular Weight:420.514
Hs Code.:

Synonyms:trans-[1-(4-cyanomethyl-cyclohexyl)-1H-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-ylmethyl]-carbamic acid tert-butyl ester

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Chemical Property of trans-[1-(4-cyanomethyl-cyclohexyl)-1H-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-ylmethyl]-carbamic acid tert-butyl ester

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Technology Process of trans-[1-(4-cyanomethyl-cyclohexyl)-1H-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-ylmethyl]-carbamic acid tert-butyl ester

There total 4 articles about trans-[1-(4-cyanomethyl-cyclohexyl)-1H-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-ylmethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 239074-29-4
trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1418003-24-3
trans-[1-(4-cyanomethyl-cyclohexyl)-1H-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-ylmethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

2.1: dimethyl sulfoxide / 4 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 120 °C / Microwave irradiation

5.1: ammonium chloride; iron / ethanol; water / 8.75 h / 80 °C

6.1: triethyloxonium fluoroborate / dichloromethane / 2 h / 20 °C

6.2: 19 h / 20 - 75 °C

With pyridine; triethyloxonium fluoroborate; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 683269-95-6
N-[trans-4-[[(methylsulfonyl)oxy]methyl]cyclohexyl]carbamic acid tert-butyl ester

: 1418003-24-3
trans-[1-(4-cyanomethyl-cyclohexyl)-1H-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-ylmethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 4 h / 90 °C

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 120 °C / Microwave irradiation

4.1: ammonium chloride; iron / ethanol; water / 8.75 h / 80 °C

5.1: triethyloxonium fluoroborate / dichloromethane / 2 h / 20 °C

5.2: 19 h / 20 - 75 °C

With triethyloxonium fluoroborate; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1313279-47-8
trans-(4-cyanomethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1418003-24-3
trans-[1-(4-cyanomethyl-cyclohexyl)-1H-1,3,5,9-tetraaza-cyclopenta[a]naphthalen-2-ylmethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 120 °C / Microwave irradiation

3.1: ammonium chloride; iron / ethanol; water / 8.75 h / 80 °C

4.1: triethyloxonium fluoroborate / dichloromethane / 2 h / 20 °C

4.2: 19 h / 20 - 75 °C

With triethyloxonium fluoroborate; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; isopropyl alcohol;