dimethyl (S_S,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate

Base Information

Chemical Name:dimethyl (S_S,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate
CAS No.:406502-78-1
Molecular Formula:C₁₇H₂₀NO₄PS
Molecular Weight:365.39
Hs Code.:

dimethyl (S<sub>S</sub>,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate

Synonyms:dimethyl (S_S,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate

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Chemical Property of dimethyl (S_S,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate

Chemical Property:

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Technology Process of dimethyl (S_S,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate

There total 1 articles about dimethyl (S_S,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350479-90-2
(S,E)-N-benzylidene-4-methylbenzenesulfinamide

: 406502-78-1
dimethyl (S_S,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C

2: 85 percent / n-BuLi / tetrahydrofuran; cyclohexane / -78 - 20 °C

With n-butyllithium; In tetrahydrofuran; cyclohexane;
DOI:10.1021/ol017289p

Reference yield: 84.0%

: 406502-78-1
dimethyl (S_S,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate

: 406502-80-5
dimethyl (2S,3R)-(-)-3-phenylaziridine-2-phosphonate

Guidance literature:: In methanol; diethyl ether; at 20 ℃; for 16h; UV-irradiation; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.05.114

Reference yield:

: 406502-78-1
dimethyl (S_S,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate

: dimethyl (S)-(+)-1-amino-2-phenylethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / MeMgBr / tetrahydrofuran; diethyl ether / -78 °C

2: 98 percent / HCO₂NH₄ / 10 percent Pd/C / methanol / 16 h

With methylmagnesium bromide; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo020707z