butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate

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Chemical Name:butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate
CAS No.:1159501-72-0
Molecular Formula:C₃₂H₄₇N₆O₈P
Molecular Weight:674.734
Hs Code.:

Synonyms:butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate

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Chemical Property of butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate

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Technology Process of butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate

There total 1 articles about butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159630-57-5
butyl (R)-4-(2-amino-3-(diethoxyphosphoryl)propanoyl)piperazine-1-carboxylate

: sodium (S)-6-(3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carboxylate

: 1159501-72-0
butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate

Guidance literature:: sodium (S)-6-(3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carboxylate; With benzotriazol-1-ol; In water; at 21 ℃; for 1h;

butyl (R)-4-(2-amino-3-(diethoxyphosphoryl)propanoyl)piperazine-1-carboxylate; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; at 20 ℃; for 64h;

Reference yield: 63.0%

: 1159501-72-0
butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate

: 1159500-34-1
4-((R)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic acid butyl ester

Guidance literature:: butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate; With trimethylsilyl bromide; In acetonitrile; at 0 - 20 ℃;

With water; In dichloromethane; acetonitrile; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00933