4-((R)-3-(bis-((isopropoxy)carbonyloxymethoxy)phosphoryl)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}propionyl)piperazine-1-carboxylic acid butyl ester

Base Information

Chemical Name:4-((R)-3-(bis-((isopropoxy)carbonyloxymethoxy)phosphoryl)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}propionyl)piperazine-1-carboxylic acid butyl ester
CAS No.:1159501-31-1
Molecular Formula:C₃₈H₅₅N₆O₁₄P
Molecular Weight:850.86
Hs Code.:

4-((R)-3-(bis-((isopropoxy)carbonyloxymethoxy)phosphoryl)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}propionyl)piperazine-1-carboxylic acid butyl ester

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Suppliers and Price of 4-((R)-3-(bis-((isopropoxy)carbonyloxymethoxy)phosphoryl)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}propionyl)piperazine-1-carboxylic acid butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((R)-3-(bis-((isopropoxy)carbonyloxymethoxy)phosphoryl)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}propionyl)piperazine-1-carboxylic acid butyl ester

Chemical Property:

Boiling Point:865.0±65.0 °C(Predicted)
Density:1.33±0.1 g/cm3(Predicted)

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-((R)-3-(bis-((isopropoxy)carbonyloxymethoxy)phosphoryl)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}propionyl)piperazine-1-carboxylic acid butyl ester

There total 2 articles about 4-((R)-3-(bis-((isopropoxy)carbonyloxymethoxy)phosphoryl)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}propionyl)piperazine-1-carboxylic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1159500-34-1
4-((R)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic acid butyl ester

: 35180-01-9
chloromethyl isopropyl carbonate

: 1159501-31-1
4-((R)-3-(bis-((isopropoxy)carbonyloxymethoxy)phosphoryl)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}propionyl)piperazine-1-carboxylic acid butyl ester

Guidance literature:: 4-((R)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic acid butyl ester; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; triethylamine; at 20 ℃; for 0.166667h;

chloromethyl isopropyl carbonate; With sodium iodide; at 45 ℃;
DOI:10.1021/acs.jmedchem.5b00933

Reference yield:

: 1159501-72-0
butyl 4-((R)-3-(diethoxyphosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidin-4-carboxamido)propanoyl)piperazine-1-carboxylate

: 1159501-31-1
4-((R)-3-(bis-((isopropoxy)carbonyloxymethoxy)phosphoryl)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}propionyl)piperazine-1-carboxylic acid butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl bromide / acetonitrile / 0 - 20 °C

1.2: 20 °C

2.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; triethylamine / 0.17 h / 20 °C

2.2: 45 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; trimethylsilyl bromide; triethylamine; In acetonitrile;
DOI:10.1021/acs.jmedchem.5b00933