4-methoxy-N-octylbenzamide

Base Information

• Chemical Name: 4-methoxy-N-octylbenzamide
• CAS No.: 145575-70-8
• Molecular Formula: C₁₆H₂₅NO₂
• Molecular Weight: 263.38
• DSSTox Substance ID: DTXSID201311266
• Nikkaji Number: J3.299.653A
• Mol file: 145575-70-8.mol

Synonyms:4-methoxy-N-octylbenzamide;N-Octyl-4-methoxybenzamide;AN-652/11992726;DTXSID201311266;AKOS003855615;145575-70-8

Chemical Property of 4-methoxy-N-octylbenzamide

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 9
• Exact Mass: 263.188529040
• Heavy Atom Count: 19
• Complexity: 235

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCCCCCCCNC(=O)C1=CC=C(C=C1)OC

Technology Process of 4-methoxy-N-octylbenzamide

There total 7 articles about 4-methoxy-N-octylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

n-Octylamine (111-86-4) + carbon monoxide (201230-82-2) + para-iodoanisole (696-62-8) → N-octyl-4-methoxybenzamide (145575-70-8)

Guidance literature:

With triethylamine; triphenylphosphine; In acetonitrile; at 125 ℃; for 1.5h; under 7500.75 Torr; Reagent/catalyst; Microwave irradiation; Inert atmosphere;

DOI:10.1021/op5003374

Reference yield: 90.0%

n-Octylamine (111-86-4) + 4-methoxyphenylacetamide (3424-93-9) → N-octyl-4-methoxybenzamide (145575-70-8)

Guidance literature:

With Fe³⁺ exchanged montmorillonite K-10; In neat (no solvent); at 140 ℃; for 30h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.12.111

Reference yield: 90.0%

n-Octylamine (111-86-4) + 2,2-diazido-1-(4-methoxyphenyl)-2-phenylethanone → N-octyl-4-methoxybenzamide (145575-70-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201900292

upstream raw materials:

n-Octylamine

4-methoxyphenylacetamide

carbon monoxide

para-iodoanisole