(S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester
CAS No.:135912-85-5
Molecular Formula:C₂₀H₂₇NO₇
Molecular Weight:393.437
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester

Chemical Property:

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Technology Process of (S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester

There total 1 articles about (S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 556-52-5
oxiranyl-methanol

: 34897-61-5
N-(benzyloxycarbonyl)-L-glutamic acid α-t-butyl ester dicyclohexylamine salt

: 135912-85-5
(S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 ℃;
DOI:10.1021/jm00099a004

Reference yield: 75.0%

: 110-91-8,99108-56-2
morpholine

: 135912-85-5
(S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester

: 135912-86-6
Z-Glu<(2S,2R)-2-hydroxy-3-(4-morpholino)propyl>-OtBu

Guidance literature:: With aluminum oxide; In diethyl ether;
DOI:10.1021/jm00099a004

Reference yield:

: 135912-85-5
(S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester

: 1054620-65-3
(6R,7S,10S)-10-Amino-7-cyclohexylmethyl-6-hydroxy-3-morpholin-4-ylmethyl-1,4-dioxa-8-aza-cyclotridecane-5,9,13-trione

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / alumina / diethyl ether

2: 56 percent / 4-(dimethylamino)pyridine (DMAP), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 °C

3: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

4: N-methylmorpholine, hydroxybenzotriazole (HOBt), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / tetrahydrofuran / 144 h / Ambient temperature

5: trifluoroacetic acid (TFA), dimethylsulfide (DMS) / Ambient temperature

With 4-methyl-morpholine; dmap; aluminum oxide; dimethylsulfide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm00099a004