(S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol

Base Information

Chemical Name:(S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol
CAS No.:151223-35-7
Molecular Formula:C₁₉H₃₃O₈PS
Molecular Weight:452.506
Hs Code.:

Synonyms:(S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol

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Chemical Property of (S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol

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Technology Process of (S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol

There total 7 articles about (S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 124-63-0
methanesulfonyl chloride

: 151223-13-1
(S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1,2,4-butanetriol

: 151223-35-7
(S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm00071a003

Reference yield:

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 151223-35-7
(S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, reflux, 5 h, 2.) THF, a) 0 deg C, 30 min, b) RT, 14 h

2: TsOH / methanol / 8 h / 60 °C

3: 98 percent / NEt₃ / CH₂Cl₂ / 2 h / 0 - 20 °C

With sodium hydride; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00071a003

Reference yield:

: 71998-69-1,86990-91-2,104973-80-0,69985-32-6
(S)-4-benzyloxy-1,2-butanediol

: 151223-35-7
(S)-4-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)-1,2,4-butanetriol

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 5.5 h / 0 - 20 °C

2: 1.) NaH / 1.) THF, reflux, 5 h, 2.) THF, a) 0 deg C, 30 min, b) RT, 14 h

3: TsOH / methanol / 8 h / 60 °C

4: 98 percent / NEt₃ / CH₂Cl₂ / 2 h / 0 - 20 °C

With dmap; sodium hydride; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00071a003