ethyl 2-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)pyrimidine-5-carboxylate

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Chemical Name:ethyl 2-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)pyrimidine-5-carboxylate
CAS No.:1552310-58-3
Molecular Formula:C₂₅H₁₉Cl₂N₅O₅S
Molecular Weight:572.428
Hs Code.:

Synonyms:ethyl 2-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)pyrimidine-5-carboxylate

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Chemical Property of ethyl 2-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)pyrimidine-5-carboxylate

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Technology Process of ethyl 2-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)pyrimidine-5-carboxylate

There total 16 articles about ethyl 2-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-sulfamoylbenzamide

: 89793-12-4
ethyl 2-chloropyrimidine-5-carboxylate

: 1552310-58-3
ethyl 2-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)pyrimidine-5-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 85 ℃;

Reference yield:

: 99-60-5
2-chloro-4-nitrobenzoic acid

: 1552310-58-3
ethyl 2-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux

2.1: hydrogenchloride; sodium nitrite / water; acetic acid / 1 h / -10 - -5 °C

2.2: 0.5 h / 0 - 10 °C

3.1: ammonia / dichloromethane; methanol / 0.08 h / 0 - 20 °C

4.1: dmap / dichloromethane / 20 °C / Reflux

5.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

7.1: trifluoroacetic acid / trifluoroacetic acid / 2 h / 20 °C

8.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 85 °C

With hydrogenchloride; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonia; water; iron; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; trifluoroacetic acid;

Reference yield:

: 61953-04-6
2-chloro-4-(chlorosulfonyl)benzoic acid

: 1552310-58-3
ethyl 2-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: ammonia / dichloromethane; methanol / 0.08 h / 0 - 20 °C

2: dmap / dichloromethane / 20 °C / Reflux

3: lithium hydroxide; water / tetrahydrofuran / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5: trifluoroacetic acid / trifluoroacetic acid / 2 h / 20 °C

6: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 85 °C

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonia; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;