N-t-butyloxycarbonyl-(1,6-diphenyl-3,3-difluoro-4(R,S)-hydroxy-5(S)-amino-hexane)

Base Information

Chemical Name:N-t-butyloxycarbonyl-(1,6-diphenyl-3,3-difluoro-4(R,S)-hydroxy-5(S)-amino-hexane)
CAS No.:147770-26-1
Molecular Formula:C₂₃H₂₉F₂NO₃
Molecular Weight:405.485
Hs Code.:

Synonyms:N-t-butyloxycarbonyl-(1,6-diphenyl-3,3-difluoro-4(R,S)-hydroxy-5(S)-amino-hexane)

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Chemical Property of N-t-butyloxycarbonyl-(1,6-diphenyl-3,3-difluoro-4(R,S)-hydroxy-5(S)-amino-hexane)

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Technology Process of N-t-butyloxycarbonyl-(1,6-diphenyl-3,3-difluoro-4(R,S)-hydroxy-5(S)-amino-hexane)

There total 4 articles about N-t-butyloxycarbonyl-(1,6-diphenyl-3,3-difluoro-4(R,S)-hydroxy-5(S)-amino-hexane) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 147770-25-0
((1S,2R)-1-Benzyl-3,3-difluoro-2-hydroxy-5-phenyl-pent-4-ynyl)-carbamic acid tert-butyl ester

: 147770-26-1
N-t-butyloxycarbonyl-(1,6-diphenyl-3,3-difluoro-4(R,S)-hydroxy-5(S)-amino-hexane)

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1h;
DOI:10.1016/0022-1139(94)03223-M

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 147770-26-1
N-t-butyloxycarbonyl-(1,6-diphenyl-3,3-difluoro-4(R,S)-hydroxy-5(S)-amino-hexane)

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / Zn dust, HgCl₂ / tetrahydrofuran / 0.5 h / Ambient temperature; sonification

2: 96 percent / H₂ / 10percent Pd/C / ethanol / 1 h

With hydrogen; mercury dichloride; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/0022-1139(94)03223-M

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 147770-26-1
N-t-butyloxycarbonyl-(1,6-diphenyl-3,3-difluoro-4(R,S)-hydroxy-5(S)-amino-hexane)

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DMSO, oxalyl chloride, 2.) NEt₃ / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) -78 deg C, 25 min

2: 32 percent / Zn dust, HgCl₂ / tetrahydrofuran / 0.5 h / Ambient temperature; sonification

3: 96 percent / H₂ / 10percent Pd/C / ethanol / 1 h

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; mercury dichloride; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/0022-1139(94)03223-M