N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine

Base Information

• Chemical Name: N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine
• CAS No.: 151012-06-5
• Molecular Formula: C₃₇H₄₅N₅O₉
• Molecular Weight: 703.792
• Mol file: 151012-06-5.mol

Synonyms:N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine

Chemical Property of N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine

There total 5 articles about N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester (151012-05-4) → Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine (151012-06-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.666667h;

DOI:10.1021/jm950803a

Reference yield:

Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginine (14611-34-8) → Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine (151012-06-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.33 h

2: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

3: 89 percent / TFA / CH₂Cl₂ / 0.67 h

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm950803a

Reference yield:

N-BOC-N-methylnorleucine (117903-25-0) → Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine (151012-06-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) conc. H₂SO₄ / 1.) dioxane, 15 min, 2.) dioxane, 5 h

2: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

3: 89 percent / TFA / CH₂Cl₂ / 0.67 h

With sulfuric acid; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm950803a

upstream raw materials:

tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginine

N-BOC-N-methylnorleucine

N-methylnorleucine tert-butyl ester

Downstream raw materials:

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl ester

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester