(1E)-1,1-dichloro-2-(4-(2-methylphenyl)-1-butenyl)-2-triisopropylsilyloxycyclopropane

Base Information

Chemical Name:(1E)-1,1-dichloro-2-(4-(2-methylphenyl)-1-butenyl)-2-triisopropylsilyloxycyclopropane
CAS No.:952315-80-9
Molecular Formula:C₂₃H₃₆Cl₂OSi
Molecular Weight:427.53
Hs Code.:

Synonyms:(1E)-1,1-dichloro-2-(4-(2-methylphenyl)-1-butenyl)-2-triisopropylsilyloxycyclopropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1E)-1,1-dichloro-2-(4-(2-methylphenyl)-1-butenyl)-2-triisopropylsilyloxycyclopropane

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Technology Process of (1E)-1,1-dichloro-2-(4-(2-methylphenyl)-1-butenyl)-2-triisopropylsilyloxycyclopropane

There total 4 articles about (1E)-1,1-dichloro-2-(4-(2-methylphenyl)-1-butenyl)-2-triisopropylsilyloxycyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 952315-68-3
(3E)-2-triisopropylsiloxy-6-(2-methylphenyl)-1,3-hexadiene

: 67-66-3,8013-54-5
chloroform

: 952315-80-9
(1E)-1,1-dichloro-2-(4-(2-methylphenyl)-1-butenyl)-2-triisopropylsilyloxycyclopropane

Guidance literature:: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; at 20 ℃; for 0.5h;
DOI:10.1021/ol7015669

Reference yield:

: 952315-67-2
6-(2-methylphenyl)-(3E)-hexen-2-one

: 952315-80-9
(1E)-1,1-dichloro-2-(4-(2-methylphenyl)-1-butenyl)-2-triisopropylsilyloxycyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / triethylamine / tetrahydrofuran / 2.5 h / 0 °C

2: 53 percent / benzyltriethylammonium chloride; aq. NaOH / 0.5 h / 20 °C

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ol7015669

Reference yield:

: 14902-36-4
3-(2-methylphenyl)-1-propanol

: 952315-80-9
(1E)-1,1-dichloro-2-(4-(2-methylphenyl)-1-butenyl)-2-triisopropylsilyloxycyclopropane

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 0.25 h / -78 °C

1.2: 72 percent / CH₂Cl₂ / -78 - 20 °C

2.1: 100 percent / triethylamine / tetrahydrofuran / 2.5 h / 0 °C

3.1: 53 percent / benzyltriethylammonium chloride; aq. NaOH / 0.5 h / 20 °C

With sodium hydroxide; oxalyl dichloride; N-benzyl-N,N,N-triethylammonium chloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation / 1.2: Wittig olefination;
DOI:10.1021/ol7015669