4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

Base Information

• Chemical Name: 4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate
• CAS No.: 1239437-95-6
• Molecular Formula: C₃₀H₃₄N₂O₆
• Molecular Weight: 518.61
• Mol file: 1239437-95-6.mol

Synonyms:4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

Chemical Property of 4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

There total 4 articles about 4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C16H20N2O3 (1332636-75-5) + 4-(chlorocarbonyl)-2-(3-methylbut-2-en-1-yl)phenyl acetate (92194-92-8) → 4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate (1239437-95-6)

Guidance literature:

In pyridine; dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm200148p

Reference yield:

N-methyl-4-hydroxypiperidine (106-52-5) → 4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate (1239437-95-6)

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

2: palladium on carbon; hydrogen / tetrahydrofuran

3: pyridine; dichloromethane / 2 h / 20 °C

With di-isopropyl azodicarboxylate; palladium on carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; pyridine; dichloromethane; 1: Mitsunobu reaction;

DOI:10.1021/jm200148p

Reference yield:

benzyl 8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamate (1239437-93-4) → 4-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate (1239437-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / tetrahydrofuran

2: pyridine; dichloromethane / 2 h / 20 °C

With palladium on carbon; hydrogen; In tetrahydrofuran; pyridine; dichloromethane;

DOI:10.1021/jm200148p

upstream raw materials:

C₁₆H₂₀N₂O₃

4-(chlorocarbonyl)-2-(3-methylbut-2-en-1-yl)phenyl acetate

N-methyl-4-hydroxypiperidine

benzyl 8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamate

Downstream raw materials:

4-hydroxy-N-(8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-yl)-3-(3-methylbut-2-enyl)benzamide