tetraethyl ((6-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene bisphosphonate

Base Information

• Chemical Name: tetraethyl ((6-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene bisphosphonate
• CAS No.: 1429012-41-8
• Molecular Formula: C₂₁H₂₉N₃O₆P₂S
• Molecular Weight: 513.491
• Mol file: 1429012-41-8.mol

Synonyms:tetraethyl ((6-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene bisphosphonate

Chemical Property of tetraethyl ((6-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene bisphosphonate

Chemical Property:

Purity/Quality:

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Technology Process of tetraethyl ((6-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene bisphosphonate

There total 1 articles about tetraethyl ((6-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromothieno[2,3-d]pyrimidin-4-amine (60703-81-3) → tetraethyl ((6-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene bisphosphonate (1429012-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 130 °C / Darkness; Inert atmosphere; Sealed tube

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / methanol / 0.33 h / 120 °C / Microwave irradiation; Inert atmosphere

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; toluene; 2: |Suzuki Coupling;

DOI:10.1021/jm400946f

Reference yield:

tetraethyl ((6-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene bisphosphonate (1429012-41-8) → (6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid (1429012-42-9)

Guidance literature:

With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2013.02.006

upstream raw materials:

6-bromothieno[2,3-d]pyrimidin-4-amine

Downstream raw materials:

(6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid