(6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid

Base Information

Chemical Name:(6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid
CAS No.:1429012-42-9
Molecular Formula:C₁₃H₁₃N₃O₆P₂S
Molecular Weight:401.276
Hs Code.:

Synonyms:(6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid

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Chemical Property of (6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid

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Technology Process of (6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid

There total 3 articles about (6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429012-41-8
tetraethyl ((6-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene bisphosphonate

: 1429012-42-9
(6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2013.02.006

Reference yield:

: 60703-81-3
6-bromothieno[2,3-d]pyrimidin-4-amine

: 1429012-42-9
(6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 130 °C / Darkness; Inert atmosphere; Sealed tube

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / methanol / 0.33 h / 120 °C / Microwave irradiation; Inert atmosphere

3: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl bromide; In methanol; dichloromethane; toluene; 2: |Suzuki Coupling;
DOI:10.1021/jm400946f

Reference yield:

: tetraethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)-amino)methylene)bis(phosphonate)

: 1429012-42-9
(6-phenylthieno[2,3-d]pyrimidin-4-ylamino)methylene bisphosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / methanol / 0.33 h / 120 °C / Microwave irradiation; Inert atmosphere

2: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl bromide; In methanol; dichloromethane; 1: |Suzuki Coupling;
DOI:10.1021/jm400946f