(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime

Base Information

• Chemical Name: (R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime
• CAS No.: 1433607-94-3
• Molecular Formula: C₂₂H₂₂FN₅O₂
• Molecular Weight: 407.447
• Mol file: 1433607-94-3.mol

Synonyms:(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime

Chemical Property of (R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime

There total 6 articles about (R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)oxime (1433607-89-6) → (R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime (1433607-94-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 4h;

Reference yield:

(E)-2-amino-7-(4-fluoro-(2-pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-acetyl oxime (1433605-24-3) → (R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime (1433607-94-3)

Guidance literature:

Multi-step reaction with 4 steps

1: butan-1-ol / tetrahydrofuran / 4 h / 30 °C / Enzymatic reaction

2: methanol; sodium hydroxide / 0.25 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; methanol; sodium hydride; sodium hydroxide; butan-1-ol; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime (1433605-33-4) → (R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime (1433607-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; sodium hydride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)oxime

(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

(E)-2-amino-7-(4-fluoro-(2-pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-acetyl oxime

(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

Downstream raw materials:

(E)-(R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(azetidin-1-yl)ethyl)oxime

(E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate