(E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate

Base Information

• Chemical Name: (E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate
• CAS No.: 1433607-99-8
• Molecular Formula: C₂₃H₂₄FN₅O₄S
• Molecular Weight: 485.539
• Mol file: 1433607-99-8.mol

Synonyms:(E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate

Chemical Property of (E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate

There total 7 articles about (E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime (1433607-94-3) + methanesulfonyl chloride (124-63-0) → (E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate (1433607-99-8)

Guidance literature:

With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)oxime (1433607-89-6) → (E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate (1433607-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(E)-2-amino-7-(4-fluoro-(2-pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-acetyl oxime (1433605-24-3) → (E)-(R)-2-(((2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-ylidene)amino)oxy)ethyl methanesulfonate (1433607-99-8)

Guidance literature:

Multi-step reaction with 5 steps

1: butan-1-ol / tetrahydrofuran / 4 h / 30 °C / Enzymatic reaction

2: methanol; sodium hydroxide / 0.25 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

5: triethylamine / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

With hydrogenchloride; methanol; sodium hydride; triethylamine; sodium hydroxide; butan-1-ol; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)oxime

(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-hydroxyethyl)oxime

methanesulfonyl chloride

(R,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

Downstream raw materials:

(E)-(R)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(azetidin-1-yl)ethyl)oxime