methyl bis(N-tert-butyloxycarbonyl-L-alanyl-L-phenylalaninolyl)phosphate

Base Information

Chemical Name:methyl bis(N-tert-butyloxycarbonyl-L-alanyl-L-phenylalaninolyl)phosphate
CAS No.:592521-43-2
Molecular Formula:C₃₅H₅₃N₄O₁₀P
Molecular Weight:720.8
Hs Code.:

Synonyms:methyl bis(N-tert-butyloxycarbonyl-L-alanyl-L-phenylalaninolyl)phosphate

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Chemical Property of methyl bis(N-tert-butyloxycarbonyl-L-alanyl-L-phenylalaninolyl)phosphate

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Technology Process of methyl bis(N-tert-butyloxycarbonyl-L-alanyl-L-phenylalaninolyl)phosphate

There total 2 articles about methyl bis(N-tert-butyloxycarbonyl-L-alanyl-L-phenylalaninolyl)phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 3279-26-3
methyl dichlorophosphite

: 82527-18-2
tert-butyl N-((1S)-2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-1-methyl-2-oxoethyl)carbamate

: 592521-43-2
methyl bis(N-tert-butyloxycarbonyl-L-alanyl-L-phenylalaninolyl)phosphate

Guidance literature:: methyl dichlorophosphite; tert-butyl N-((1S)-2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-1-methyl-2-oxoethyl)carbamate; With 2,4,6-trimethyl-pyridine; In tetrahydrofuran; at 20 ℃; for 4h;

With iodine; In tetrahydrofuran; water; at 20 ℃; for 0.75h;
DOI:10.1021/jo034471q

Reference yield:

: 2280-66-2
N-tert-butyloxycarbonylalanylphenylalanine methyl ester

: 592521-43-2
methyl bis(N-tert-butyloxycarbonyl-L-alanyl-L-phenylalaninolyl)phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / NaBH₄ / tetrahydrofuran; methanol / 0.83 h / 60 °C

2.1: 2,4,6-collidine / tetrahydrofuran / 4 h / 20 °C

2.2: 51 percent / I₂ / tetrahydrofuran; H₂O / 0.75 h / 20 °C

With 2,4,6-trimethyl-pyridine; sodium tetrahydroborate; In tetrahydrofuran; methanol;
DOI:10.1021/jo034471q