3279-26-3

Basic information

• Product Name: METHYL PHOSPHORODICHLORIDITE
• Synonyms: METHYL DICHLOROPHOSPHITE, TECHNICAL GRADE;Methoxydichlorophosphine;Methoxyphosphonous Dichloride;O-Methyl Phosphorodichloridit;O-Methyl Phosphorodichloridite;Methyl Dichlorophosphite [Phosphitylating Agent];Dichloridophosphorous acid methyl ester;Methyl dichlorophosphite,98%
• CAS NO: 3279-26-3
• Molecular Formula: CH₃Cl₂OP
• Molecular Weight: 132.91
• EINECS: 221-915-3
• Product Categories: Pyridine;All Aliphatics;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Phosphorylating and Phosphorothioating Agents;Phosphorylation;Protecting Agents, Phosphorylating Agents & Condensing Agents;Synthetic Organic Chemistry;Aliphatics;Phosphorylating and Phosphitylating Agents;Building Blocks;Chemical Synthesis;Organic Building Blocks;Phosphorus Compounds;Phosphorus Halides
• Mol File: 3279-26-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: −91 °C(lit.)
• Boiling Point: 93-95 °C(lit.)
• Flash Point: 104 °F
• Appearance: /liquid
• Density: 1.376 g/mL at 20 °C(lit.)
• Vapor Pressure: 66.3mmHg at 25°C
• Refractive Index: n20/D 1.474(lit.)
• Storage Temp.: −20°C
• Water Solubility: Reacts with water. Soluble in chloroform, dichloromethane and ethyl acetate.
• Sensitive: Moisture Sensitive
• Stability: Flammable.
• BRN: 1697452
• CAS DataBase Reference: METHYL PHOSPHORODICHLORIDITE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL PHOSPHORODICHLORIDITE(3279-26-3)
• EPA Substance Registry System: METHYL PHOSPHORODICHLORIDITE(3279-26-3)

Safety Data

• Hazard Codes: C
• Statements: 10-14-34-37
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2920 8/PG 2
• WGK Germany: 3
• F: 10-13-23
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 3279-26-3(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Liquid

Uses

Different sources of media describe the Uses of 3279-26-3 differently. You can refer to the following data:
1. Employed in the synthesis of phosphorodichloridothioates1 and oxazaphosphorinanes2 from sulfenyl chlorides and a chiral amino alcohol, respectively.
2. Methyl dichlorophosphite has been employed in the preparation of:phosphonamidate- and phosphonate-linked phosphonopeptides2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcoholdeoxyoligonucleotides on a polymer supportcis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinanephosphorodichloridothioates oxazaphosphorinanes

InChI:InChI=1/CH3Cl2OP/c1-4-5(2)3/h1H3

Upstream product

• 3743-07-5 dimethyl chlorophosphite 
• 67-56-1 methanol 
• 1825-61-2 Trimethylmethoxysilane 
• 7646-78-8 tin(IV) chloride 
• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 3741-36-4 methoxy-2 dioxaphospholane-1,3,2 
• 26964-02-3 1,1-Dimethylaethylenmethylphosphit 
• 89983-14-2 bis-(pyrrolidino) methoxyphosphine 
• 23985-58-2 3-hydroxy-2-methyl-3-phenyl-propionic acid 
• 86030-43-5 N,N-diisopropylmethylphosphonamidic chloride 
• 92611-10-4 bis(N,N-diisopropylamino)methoxyphosphine 
• 79607-36-6 Phosphorochloridous acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester 
• 1027989-03-2 Phosphorous acid benzyl ester 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester methyl ester 
• 99109-20-3 [Benzyloxycarbonylamino-(4-chloro-phenyl)-methyl]-phosphonic acid monomethyl ester 
• 58455-89-3 methyl 1-(benzyloxycarbonylamino)benzyl phosphonate 
• 1005-69-2 2-methoxy-5,5-dimethyl-1,3,2-dioxaphosphorinane 
• 592521-43-2 methyl bis(N-tert-butyloxycarbonyl-L-alanyl-L-phenylalaninolyl)phosphate 
• 31121-06-9 2-methoxy-[1,3,2]dioxaphosphinane 

Relevant articles and documents

Synthesis and properties of 4-(dibromomethyl)benzenecarbaldehyde

4-(Dibromomethyl)benzenecarbaldehyde was synthesized for the first time using a new method which also allowed the co-preparation of terephthalic aldehyde. The reaction of this aldehyde with primary amines resulted in the formation of imines, including those containing an additional acetal group, while the reaction with trialkyl orthoformates led to the formation of acetals. The latter compounds were transformed into 4-(dibromomethyl)-substituted benzenes containing a phosphorus functional group in the side chain via consecutive reactions with phosphorus trichloride and the esters of P(III) acids.

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