4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Chemical Name:4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine
CAS No.:1396087-13-0
Molecular Formula:C₃₄H₃₅FN₁₀O₃
Molecular Weight:650.716
Hs Code.:

Synonyms:4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Chemical Property of 4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Technology Process of 4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

There total 3 articles about 4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1396087-06-1
4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(prop-1-en-2-yl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1396087-13-0
4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: With sodium azide; trifluoroacetic acid; In chloroform; at -15 - 80 ℃; for 4.5h;
DOI:10.1021/jm300846z

Reference yield:

: 1253573-75-9
4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1396087-13-0
4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C

2: potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 24 h / 80 °C

3: sodium azide; trifluoroacetic acid / chloroform / 4.5 h / -15 - 80 °C

With sodium azide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; chloroform; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm300846z

Reference yield:

: 886372-63-0
5-fluoro-6-methoxypyridin-3-ylamine

: 1396087-13-0
4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C

2: potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 24 h / 80 °C

3: sodium azide; trifluoroacetic acid / chloroform / 4.5 h / -15 - 80 °C

With sodium azide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; chloroform; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm300846z