cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane

Base Information

• Chemical Name: cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane
• CAS No.: 416844-05-8
• Molecular Formula: C₂₃H₁₈O₃
• Molecular Weight: 342.394
• Mol file: 416844-05-8.mol

Synonyms:cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane

Chemical Property of cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane

There total 3 articles about cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide (845869-50-3) + 4-iodobenzoic acid (619-58-9) → cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane (416844-05-8)

Guidance literature:

4-iodobenzoic acid; With isopropylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 1.5h;

(1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/jo049697n

Reference yield:

((1R,2S,3R)-2,3-Diphenyl-cyclopropyl)-imidazol-1-yl-methanone → cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane (416844-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 0 - 20 °C

2.1: isopropyl magnesium chloride / tetrahydrofuran / 1.5 h / -78 °C

2.2: 83 percent / tetrahydrofuran / -78 - 20 °C

With isopropylmagnesium chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo049697n

Reference yield:

(1α,2β,3β)-2,3-diphenylcyclopropanecarboxylic acid (42842-79-5) → cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane (416844-05-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 0.5 h / 0 °C

2.1: CH₂Cl₂ / 0 - 20 °C

3.1: isopropyl magnesium chloride / tetrahydrofuran / 1.5 h / -78 °C

3.2: 83 percent / tetrahydrofuran / -78 - 20 °C

With isopropylmagnesium chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo049697n

upstream raw materials:

(1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide

4-iodobenzoic acid

(1α,2β,3β)-2,3-diphenylcyclopropanecarboxylic acid