(1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide

Base Information

• Chemical Name: (1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide
• CAS No.: 845869-50-3
• Molecular Formula: C₁₈H₁₉NO₂
• Molecular Weight: 281.354
• Mol file: 845869-50-3.mol

Synonyms:(1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide

Chemical Property of (1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide

There total 2 articles about (1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((1R,2S,3R)-2,3-Diphenyl-cyclopropyl)-imidazol-1-yl-methanone + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide (845869-50-3)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo049697n

Reference yield:

(1α,2β,3β)-2,3-diphenylcyclopropanecarboxylic acid (42842-79-5) → (1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide (845869-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.5 h / 0 °C

2: CH₂Cl₂ / 0 - 20 °C

In dichloromethane;

DOI:10.1021/jo049697n

Reference yield: 91.0%

(1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide (845869-50-3) + 3-Iodobenzoic acid (618-51-9) → cis-2,3-diphenyl-1-benzoyl(meta carboxylic acid)cyclopropane (845727-31-3)

Guidance literature:

3-Iodobenzoic acid; With isopropylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 1.5h;

(1R,2S,3R)-2,3-Diphenyl-cyclopropanecarboxylic acid methoxy-methyl-amide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/jo049697n

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

(1α,2β,3β)-2,3-diphenylcyclopropanecarboxylic acid

Downstream raw materials:

cis-2,3-diphenyl-1-benzoyl(para carboxylic acid)cyclopropane

cis-2,3-diphenyl-1-benzoylcyclopropane

cis-2,3-diphenyl-1-benzoyl(meta carboxylic acid)cyclopropane